基于卡帕卡拉基和酸的响应pH的水凝,用于可控释放甲醇
Muhammad Anees Ur Rehman Qureshi1, Nasima Arshad1, Atta Rasool2
1Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan.
Royal Society open science
|April 25, 2024
概括
新的生物降解水凝由卡拉基南,酸和聚乙烯醇制成,为化疗药物输送提供了一个有前途的平台. 这些生物相容材料表现出高效的甲状腺酸荷载和释放,有助于癌症治疗.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 癌症仍然是一个重大的全球健康挑战,化疗是主要的治疗方式.
- 传统的化疗药物由于其物理化学性质,往往会引起严重的副作用.
- 开发先进的药物输送系统对于提高癌症治疗效率和患者的治疗结果至关重要.
研究的目的:
- 为了合成和表征新的树枝状凝,以增强化疗输送.
- 评估开发的水凝系统的生物降解性,细胞相容性和药物释放动力学.
- 评估这些水凝在癌症治疗中作为甲状腺素 (MTX) 载体的潜力.
主要方法:
- 使用溶液造方法,制备了聚胺胺胺胺) 树状甲素 (CG),酸 (SA) 和聚乙烯醇 (PVA) 水凝.
- 使用3-aminopropyl(diethoxy) methyl silane (APDMS) 进行交叉链接,并使用FTIR,TGA,SEM和AFM进行表征.
- 进行了体外生物降解,细胞兼容性测定 (DF-1纤维细胞) 和药物释放研究 (在不同pH下在PBS中的MTX).
主要成果:
- 合成的CG/SA/PVA水凝在pH范围5-7之间表现出最佳的胀.
- 实验室研究证实了水凝的生物降解性和无毒性.
- 从CAP-8水凝中释放的甲托雷克萨特 (MTX) 显示在pH 7.4下释放81.25%,在pH 5.3下释放77.23%在13.5小时内,遵循超级案例II传输机制.
结论:
- 与APDMS交叉连接的CG/SA/PVA树状液体水凝代表了针对性化疗药物输送的可行和高效平台.
- 这些水凝显示出对甲状腺的控制释放有很好的潜力,为癌症治疗提供了有前途的方法.
- 水凝的生物相容性和生物降解性使其更适合于瘤学中的生物医学应用.
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