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与型肝炎3型感染相关的肝细胞癌的危险因素:系统性审查

Hamzah Z Farooq¹, Michael James², Jane Abbott²

¹Blizard Institute, Queen Mary University of London, London E1 2AT, United Kingdom. hamzah.farooq@qmul.ac.uk.

World journal of gastrointestinal oncology

|April 25, 2024

概括

肝炎C病毒基因型-3 (HCV-G3) 感染会增加肝细胞癌 (HCC) 的风险. 肝硬化和年龄已被确定为风险因素,但需要更多的研究才能充分了解HCV-G3患者的HCC发展.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
在瘤学瘤学.

背景情况:

型肝炎病毒 (HCV) 影响全球7900万,导致显著的发病率和死亡率.
慢性HCV感染可能导致肝硬化和肝细胞癌 (HCC).
3型HCV基因型 (HCV-G3) 占感染的17.9%,对抗病毒药物反应较弱,即使没有肝硬化,HCC风险也增加.

研究的目的:

系统地审查和批判性地评估HCV-G3.3继发性HCC的风险因素.
从1946年到2023年,综合现有的有关HCV-G3引起的HCC风险因素的文献.

主要方法:

系统审查已发表的关于HCV-G3.3对HCV二次性HCC风险因素的研究.
在科学网,Medline,EMBASE和CENTRAL数据库中搜索相关出版物 (1946-2023年).
包括七项研究 (3个病例控制,2个队列,1个横截面) 总共有9621名参与者.

主要成果:

在所有七项研究中,肝硬化被确定为HCC的危险因素.
在五项研究中,较高的年龄是危险因素.
在两项研究中,男性性别,高α-fetoprotein,直接作用的抗病毒治疗和持续的病毒学反应都是风险因素.

结论:

感染HCV基因型-3是最终阶段肝病,HCC和肝脏相关死亡的独立风险因素.
对于HCV-G3.3次要的HCC的特定风险因素的证据有限.
肝硬化和年龄是相关的危险因素,但由于研究数量少,需要进一步研究.

关键词:

通过血液传播的病毒.3 基因型 3 基因型在C型肝炎患者中,C型肝炎是最常见的.肝细胞癌是肝细胞癌.肝癌是一种肝癌.系统性审查系统性审查

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