我们是否应该在45岁以下的人群中进行结直肠癌查的西格莫视镜检查?
Waiian Leong1,2, Jia-Qi Guo1, Chun Ning1
1Division of Gastroenterology & Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong Province, China.
World journal of gastrointestinal oncology
|April 25, 2024
概括
在45岁以下的个人中,结肠直肠癌查显示左结肠中腺瘤多 (AP) 的患病率较高. 灵活的半导体镜可能是这个年龄组更具成本效益的初始查策略.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 结肠直肠癌 (CRC) 的预防依赖于查腺瘤多体 (AP).
- 目前的指导方针建议对45岁及以上的个人进行结肠镜检查.
- 对于45岁以下的个体,查策略仍未确定.
研究的目的:
- 在45岁及以下的患者中,比较左结肠和右结肠之间的APs和高度瘤的患病率.
- 评估在这个人口群体中进行多眼切除术后监测的有效性.
主要方法:
- 在中国的一家三级医院进行了一项回顾性观察性研究.
- 包括18-45岁的患者,接受初始结肠镜检查,诊断出AP或高度瘤 (2014年2月 - 2021年1月).
- 评估了整个结肠中的AP患病率,以及在多角切除术后的1-3年监测期间.
主要成果:
- 总共分析了3053名患者.
- APs的患病率在左结肠 (55.0%) 与右结肠 (41.6%) 相比较高.
- 高度瘤的患病率在左结肠 (2.7%) 与右结肠 (0.9%) 相比显著更高.
- 术后监测 (n=327) 在66.1%的病例中发现了复发性AP.
结论:
- 左结肠在45岁及以下的患者中表现出更高的APs和高度瘤的患病率.
- 灵活的半导体镜被认为是最优,最具成本效益和最安全的初始查方法.
- 进一步的研究可能会完善年轻成年人患结直肠癌风险的查方案.
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