急性中度常态性缺氧不会改变循环甲状腺激素度,这种度是由1小时的头向外冷水浸泡引起的
Jason M Keeler1, Joel T Greenshields1, Curtis S Goss1
1Department of Kinesiology, Indiana University School of Public Health-Bloomington, Bloomington, Indiana, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|April 25, 2024
概括
急性冷水浸泡会激活甲状腺激素,但中度低氧不会改变这种反应. 这表明缺氧在寒冷暴露适应期间不会影响甲状腺激素的变化.
科学领域:
- 环境生理学环境生理学
- 内分泌学 在内分泌学.
- 人类适应寒冷的过程
背景情况:
- 暴露于寒冷会刺激热生成,并激活下丘脑-垂体-甲状腺轴.
- 低氧在冷水浸泡期间调节甲状腺激素反应中的作用尚不清楚.
研究的目的:
- 调查急性中度常态性缺氧是否会在冷水浸泡 (HOWI) 期间影响循环甲状腺激素度.
- 为了比较甲状腺激素反应在寒冷的HOWI下在normoxic和hypoxic条件下.
主要方法:
- 一项随机交叉单盲研究,涉及12名健康成年人.
- 参与者接受了1小时的冷水浸泡 (22°C) 头向外的水浸泡,呼吸的是normobaric normoxia或normobaric hypoxia.
- 测量包括甲状腺激素 (T3,T4,TSH),动脉氧血球蛋白和和核心温度.
主要成果:
- 寒冷的HOWI在normoxic和hypoxic条件下降低了核心温度,而它们之间没有显著差异.
- 循环甲状腺刺激激素 (TSH),自由甲状腺素 (T4) 和三甲状腺素 (T3) 度随着时间的推移而变化,但在正常和缺氧条件之间没有显著差异.
- 急性中度诺莫巴里克缺氧在1小时的冷HOWI期间没有改变循环甲状腺激素的反应.
结论:
- 急性中度常态缺氧在冷水浸泡时不会改变甲状腺激素反应.
- 甲状腺激素度因缺氧引起的变化不太可能对重复暴露在冷水中的适应造成严重影响.
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