出生时的甲基化概况与早期儿童肥胖有关
Delphine Lariviere1, Sarah J C Craig2,3, Ian M Paul3,4
1Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, USA.
Journal of developmental origins of health and disease
|April 25, 2024
概括
新的研究表明,在出生时婴儿的DNA甲基化概况可以预测体重增加和六个月的肥胖风险. 这些发现突出了表观基因组因素作为儿童肥胖干预的关键早期指标.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 儿科 儿科 儿科
- 代谢健康 代谢健康
背景情况:
- 儿童肥胖是一个主要的全球健康问题,需要识别早期的风险因素.
- 基因组,微生物组和表观基因组因素都与肥胖症的发展有关.
- 早期的表观遗传学,特别是DNA甲基化,可以提供对婴儿体重轨迹的预测见解.
研究的目的:
- 调查出生时的DNA甲基化概况 (带血和胎盘) 与六个月的婴儿体重结果之间的关联.
- 确定特定的基因并开发与婴儿体重增加和肥胖风险相关的预测得分.
- 探索表观基因组修饰在早期肥胖发展中的作用.
主要方法:
- 在48名婴儿中使用Illumina Infinium MethylationEpic芯片进行全基因组DNA甲基化分析.
- 分析包括儿童/母亲健康和环境因素.
- 回归分析以确定可预测体重结果的甲基化概况 (有条件的体重增加,BMI,体重与长度比率).
主要成果:
- 在带血中确定了23个预测基因,在胎盘中确定了10个与婴儿体重结果相关的基因.
- 三个带血基因 (PLIN4,UBE2F,PPPP1R16B) 始终在独立的队列中预测了所有三个体重结果,并得到了验证.
- 开发了一种甲基化风险评分 (MRS) 来识别儿童肥胖风险较高的婴儿.
结论:
- 婴儿出生时的DNA甲基化概况与生命前六个月的体重结果有显著的关联.
- 特定的基因和开发的MRS显示了早期识别儿童患肥胖风险的潜力.
- 这些发现强调了表观遗传学因素在早期肥胖中的重要性,并需要进一步的功能性研究.
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