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Updated: Jun 28, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
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生物物理刺激用于骨再生,使用酸/酸铁电复合物

Razvan Rotaru1, Violeta Melinte1, Ioana-Sabina Trifan1

  • 1"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Romania. trifan.sabina@icmpp.ro.

Physical chemistry chemical physics : PCCP
|April 25, 2024
PubMed
概括

我们开发了一种新的酸/酸纳米复合物,具有出色的生物相容性和压电性质,用于生物医学用途. 这种铁电材料显示出加速骨再生的潜力.

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
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Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...