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表观遗传年龄与2型糖尿病或血糖特征之间的关联:一项纵向双胞胎研究
Ke Miao1,2, Xuanming Hong1,2, Weihua Cao1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
像禁食血葡萄糖这样的血糖特征与更快的表观遗传衰老 (DunedinPACE) 和衰老加速 (PC GrimAge Acceleration) 有关. 管理血糖可能会减缓生物衰老,减少与年龄相关的疾病.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
- 代谢健康 代谢健康
背景情况:
- 表观遗传时钟,如DunedinPACE和主要组件 (PC) 时钟,作为衰老生物标志物.
- 以前的研究表明表观遗传衰老与2型糖尿病 (T2DM) 之间存在多种关联.
研究的目的:
- 调查表观遗传年龄指标与T2DM或血糖特征之间的关联.
- 使用纵向数据探索表观遗传衰老和血糖特征之间的时间关系.
主要方法:
- 利用了中国国家双胞胎登记处的1070名双胞胎的DNA甲基化数据.
- 计算的表观遗传年龄指标包括PCGrimAge加速 (PCGrimAA),PCPhenoAge加速 (PCPhenoAA) 和DunedinPACE.
- 采用混合效应和交叉延迟建模用于横截面和时间分析.
主要成果:
- 横截面分析显示,DunedinPACE与血糖特征之间存在积极关联,PCPhenoAA与禁食血葡萄糖之间存在积极关联.
- 纵向分析显示,血糖特征 (禁食血葡萄糖,HbA1c,TyG指数) 在DunedinPACE的增加之前.
- TyG指数也在PCGrimAA上升之前出现,这表明存在时间联系.
结论:
- 血糖特征与表观遗传年龄指标积极相关,特别是DunedinPACE.
- 血糖特征似乎先于表观遗传衰老标志物的增加.
- 针对血糖控制的干预措施可能会减少表观遗传衰老和相关的并发症.
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