牛皮的全身治疗和皮肤感染的风险
Yuko Higashi1, Shinichi Imafuku2, Noriko Tsuruta3
1Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
The Journal of dermatology
|April 25, 2024
概括
系统性牛皮治疗可以增加皮肤感染的风险,特别是病毒感染的风险. 皮肤科医生应在治疗期间监测患者是否有这些不良事件.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 系统性治疗对于中度至重度的牛皮至关重要,但可能导致感染.
- 严重的系统性感染的风险是已知的,但皮肤感染风险的理解较少.
- 这项研究调查了接受生物治疗的牛皮患者皮肤感染的频率.
研究的目的:
- 为了确定皮肤细菌,病毒和真菌感染在接受全身生物治疗的牛皮患者的发病率.
- 确定与这些感染相关的风险因素,包括特定药物类别和患者病史.
主要方法:
- 2020年,西日本牛皮登记处对878名患者进行了后续调查.
- 分析患者数据,包括牛皮表型,处方的全身药物和记录的皮肤感染.
- 多变量分析以确定与感染风险增加相关的因素.
主要成果:
- 皮肤感染发生在1.37% (细菌),1.25% (病毒) 和5.13% (真菌) 的患者中.
- 瘤坏死因子α和IL-17抑制剂与细菌感染有关.
- 中耳炎史和口服药物使用与病毒感染有关.
- 年龄和IL-17抑制剂与真菌感染相关.
结论:
- 牛皮的全身疗法与皮肤感染,特别是病毒感染的风险增加有关.
- 特定的生物药物 (TNF-α,IL-17抑制剂) 和患者因素影响感染风险.
- 皮肤科医生必须对接受全身牛皮治疗的患者的皮肤感染保持警.
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