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Updated: Jun 27, 2025

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
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Published on: April 19, 2013

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在SLC30A8位点的多个遗传变异会影响当地的超强增强剂活性,并影响胰腺β细胞的存活和功能

Ming Hu1, Innah Kim1, Ignasi Morán2

  • 1Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|April 25, 2024
PubMed
概括

接近SLC30A8基因的遗传变异会影响2型糖尿病 (T2D) 的风险. 增强剂在β细胞中的删除减少了SLC30A8表达和改善了胰岛素分泌,这表明它在已知的R325W变异之外发挥了作用.

关键词:
在CRISPR-Cas9基因组编辑中.在GWAS中,GWAS就是GWAS.这就是T2D.一个案例,一个案例.在这种情况下,染色染色素基因 基因 基因 基因风险变体的风险变体这是一个超级增强器.转录规则 转录规则 转录规则

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