结直肠癌和随后的糖尿病风险:台湾的一项基于人口的队列研究
Hsin-Yin Hsu1,2,3, Yih-Jong Chern4, Min-Shu Hsu5
1Department of Family Medicine, Mackay Memorial Hospital, Taipei City 104217, Taiwan.
The Journal of clinical endocrinology and metabolism
|April 25, 2024
概括
结肠直肠癌 (CRC) 患者面临患上糖尿病的风险更高. 长期化疗进一步增加了这种风险,这强调了对CRC幸存者的警血糖监测的需要.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 大肠直肠癌 (CRC) 和新发糖尿病 (DM) 之间的关系尚未得到充分证实.
- 了解这种关联对于患者管理和风险分层至关重要.
研究的目的:
- 调查CRC与随后发展DM的风险之间的关联.
- 为了评估化疗对DM风险的影响,在患有CRC的患者.
主要方法:
- 一项全国性的队列研究利用了台湾癌症注册表和链接的健康数据库 (2007-2018).
- 86,268名CRC患者的倾向评分与一般人口队列相匹配.
- 化学疗法暴露被根据持续时间 (<90天,90-180天,在3年内超过180天) 分类.
主要成果:
- 与一般人群相比,CRC患者患DM的风险增加了14% (HR: 1.14).
- 患DM的风险在诊断后的第一年内最高,并且长期保持较高.
- 长期化疗 (>180天) 与随后的DM风险增加60-70%有关 (HR: 1.64).
结论:
- 结肠直肠癌与患上糖尿病的风险增加有关.
- 长时间的化疗,特别是用capecitabine,显著增加了CRC患者的DM风险.
- 定期的血糖监测对于CRC患者至关重要,特别是那些接受长期化疗方案的人.
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