在T细胞淋巴瘤患者中治疗自身移植后复发的治疗方法
Olivier Veilleux1,2, Francisco Socola2, Sally Arai2
1Department of Medicine, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
American journal of hematology
|April 25, 2024
概括
对外围T细胞淋巴瘤 (PTCL) 的自身造血细胞移植 (AHCT) 显示了40%的复发率. 随后的异构HCT为符合条件的患者提供72%的3年总生存率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 周围T细胞淋巴瘤 (PTCL) 是一种具有攻击性,异质的血液性恶性瘤,预后不佳.
- 自主造血细胞移植 (AHCT) 是PTCL的标准整合疗法.
- 在AHCT后的疾病复发仍然是一个重大挑战,需要有效的救援策略.
研究的目的:
- 在PTCL患者中分析AHCT后疾病复发的模式.
- 评估不同治疗方法的结果,以管理AHCT后复发的PTCL.
- 评估异构HCT作为复发后的救援疗法的疗效.
主要方法:
- 在2008年至2020年期间接受AHCT的124名PTCL患者的回顾性分析.
- 在AHCT后,随访时间的中位数为6.01年.
- 评估复发发病率,救援疗法和整体存活率 (OS).
主要成果:
- 49名患者 (40%) 在AHCT后经历了疾病复发.
- 不处于第一次完全缓解期的患者的复发率更高.
- 在复发患者中,70%的患者接受了全身疗法,将其桥接到全原性HCT,而53%的患者接受了该程序.
- 在接受异构HCT复发后的患者中,三年后的生存率为72%.
结论:
- 对于PTCLs,AHCT后复发很常见,特别是在没有达到第一个完全缓解的患者中.
- 异构HCT可以成为AHCT后复发PTCL的有效救援选择,实现显著的长期存活.
- 对优化复发PTCL救援策略的进一步研究是有必要的.
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