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Updated: Jun 27, 2025

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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基于结构的合理和一般战略稳定单链T细胞受体以增强亲和力

Jia-Ling Zou1, Kai-Xiang Chen2, Xiao-Juan Wang2

  • 1Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Journal of medicinal chemistry
|April 25, 2024
PubMed
概括

工程化单链T细胞受体 (scTCRs) 显示出更好的稳定性和可溶性. 这一进步有助于开发具有增强亲和力和保留特异性的T细胞受体治疗药物.

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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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