精密共生菌增加肠道微生物群的多样性,并改善胃肠道症状在自闭症谱系障碍的开放标签试点研究中
Joann Phan1, Diana C Calvo2, Divya Nair1
1Sun Genomics, Inc., San Diego, California, USA.
mSystems
|April 25, 2024
概括
精密协生菌调节了自闭症谱系障碍 (ASD) 患者的肠道微生物组,改善了胃肠道和ASD相关症状. 这项研究强调了协生菌作为ASD管理治疗方法的潜力.
科学领域:
- 肠道微生物组研究研究
- 神经发育障碍 神经发育障碍
- 精准医学是一门精准的医学.
背景情况:
- 自闭症谱系障碍 (ASD) 影响了36个美国儿童中的1个,造成了严重的健康和经济负担.
- 以前试图将肠道微生物群与自闭症相关联的尝试产生了不一致的结果.
- 有限的研究规模阻碍了理解ASD相关微生物组的进展.
研究的目的:
- 研究精密共生补充剂对肠道微生物群和ASD儿童和成人症状的影响.
- 与神经类型对照相比,分析ASD参与者的微生物组成,代谢途径和遗传潜力.
- 为了评估与ASD相关的变化和胃肠道 (GI) 症状在协生性干预后.
主要方法:
- 整个元基因组猎枪测序被用于微生物分类和功能潜力分析.
- 在3个月的时间里,对170名ASD参与者进行了精确的共生补充剂.
- 基线和补充后的评估包括ASD/GI症状调查和深度元基因组测序.
主要成果:
- 与对照组相比,ASD队列表现出较低的基线α多样性和独特的微生物组成,具有更高的潜在病原体和更低的有益微生物.
- 根据社会反应和饮食模式,在ASD队列中观察到肠道微生物的显著差异.
- 随着协生补充后,ASD参与者表现出更多的α多样性,改变了微生物分类学和代谢潜力,改善了胃肠道不适,语言,理解,认知和言语.
结论:
- 精密协生菌有效调节了ASD患者的肠道微生物组.
- 同生菌补充剂显示出改善胃肠道和核心ASD相关症状的潜力.
- 需要进一步的研究,承认在开放标签设计中潜在的安慰剂效应.
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