系统性综述与元分析:益生菌对刺激性肠综合征的影响
Q Qing1, Y Chen2, D K Zheng2,3
1Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, No. 63, Duobao Road, Liwan District, Guangzhou, Guangdong province, 510150, P.R. China.
Beneficial microbes
|April 25, 2024
概括
益生菌真菌,特别是Saccharomyces,显示出缓解刺激性肠综合征 (IBS) 患者腹痛的潜力. 虽然通常是安全的,但需要更多的研究来确认它们对IBS症状管理的整体有效性.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 临床研究 临床研究
背景情况:
- 刺激性肠综合征 (IBS) 带来了重大的临床挑战.
- 益生菌真菌正在成为IBS的潜在治疗候选者.
- 对其临床疗效和安全性的系统评估是有限的.
研究的目的:
- 系统地审查和元分析益生菌在IBS治疗中的有效性和安全性.
- 评估益生菌对各种IBS症状和心理结果的影响.
- 评估益生菌在IBS患者中的安全性.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在PubMed,Embase,Web of Science和Cochrane图书馆进行的搜索截至2022年6月.
- 包括涉及受试者接受益生菌治疗的RCT;使用标准化平均差异 (SMD) 汇总的数据.
主要成果:
- 分析了7项涉及883名受试者的试验.
- 萨卡罗米克斯证明了腹部疼痛/不适的显著减少 (SMD = -0.205,P = 0.005).
- 在心理结果和便形式上注意到了潜在的改善,但对其他IBS症状的影响是不确定的;发生了轻微的并发症,但没有报告严重的不良事件.
结论:
- 益生菌真菌,特别是Saccharomyces,可以提供部分缓解症状,并为IBS提供有利的安全性.
- 目前的证据表明相对安全和部分疗效,但不足以做出最终结论.
- 进一步的高质量,大规模试验和现实研究对于确定实际益处和探索新的真菌菌株至关重要.
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