与杜皮卢马布使用相关的角膜并发症
Jenna Tauber1, David C Ritterband, Joann J Kang
1Manhattan Eye, Ear and Throat Hospital/ Northwell Eye Institute (J.T., D.C.R.), New York, NY; and Department of Ophthalmology (J.T., J.J.K.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Eye & contact lens
|April 25, 2024
概括
杜皮卢马布 (Dupilumab) 是一种治疗亚托邦性皮炎的药物,可导致严重的角膜并发症,如角膜炎. 早期检测和停止药物,以及类固醇治疗,有效地管理这些罕见的眼睛问题.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 杜皮卢马布是一种生物疗法,越来越多地用于亚托邦性皮肤炎.
- 虽然结膜炎是已知的副作用,但严重的眼部并发症并不常见.
- 非典型的角膜问题需要临床医生提高认识.
研究的目的:
- 报告使用dupilumab的患者观察到的异常角膜并发症.
- 要突出与杜皮卢马布治疗相关的眼部不良事件的范围.
主要方法:
- 一个由四名经历角膜并发症的成年患者组成的病例系列.
- 患者被诊断为浸性或性角膜炎.
- 角膜疾病与杜比卢马布用于亚托皮炎的使用有关.
主要成果:
- 在开始使用dupilumab后,所有四名患者都出现了角膜病变 (透性或性).
- 停止使用dupilumab和局部皮质类固醇在所有病例中都解决了角质炎.
- 两名患者因疑似感染而接受了预防性抗生素.
结论:
- 医生应该考虑严重的角膜并发症作为dupilumab的潜在不良影响.
- 及时识别和干预,包括停止使用药物和局部类固醇,对于管理与dupilumab相关的角质炎至关重要.
相关概念视频
01:25Glaucoma: Overview
560
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
560
01:28Angle Closure Glaucoma: Treatment
485
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
485