白物质微观结构的基础轻度行为障碍在帕金森病的疾病
Oury Monchi1,2,3,4, Gabriel D Pinilla-Monsalve1,2, Hannes Almgren3,4
1Centre de recherche de l'Institut universitaire de gériatrie de Montréal, Montreal, Quebec, Canada.
概括
帕金森病 (PD) 中的轻度行为障碍 (MBI) 与关键大脑区域的白质连接改变有关. 这项研究使用dMRI揭示与MBI相关的神经结构变化在早期到中期PD患者.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 呈现出行为,个性和认知变化,甚至在早期.
- 轻度行为障碍 (MBI) 是PD认知衰退的潜在早期标志物.
- 在早期到中期的PD中,MBI的神经结构的基础尚不清楚.
研究的目的:
- 为了研究与MBI和轻度认知障碍 (MCI) 相关的白质微观结构变化,在早期到中期的PD.
- 利用扩散磁共振成像 (dMRI) 来探索这些神经结构的基础.
主要方法:
- 招募了91名PD患者和36名健康对照.
- 获得的解剖MRI和dMRI数据.
- 进行神经心理测试和轻度行为障碍检查清单.
- 分析了白质完整性,使用分数异构性 (FAt),辐射扩散性 (RDt),自由水 (FW) 和表面纤维密度 (AFD).
主要成果:
- 患有MBI的PD患者表现出左桃体-膜连接受损 (增加RDt,减少AFD和FAt).
- 患有MBI和MCI的PD患者在左轨道前环 (OrG) -海马连接中表现出增加的自由水.
- 这些患者还与杏仁体 (增加RDt) 和尾状核 (增加RDt,减少AFD) 的右OrG连接发生了变化.
结论:
- 在PD中,MBI与异常的白质微观结构有关,其中涉及轨道前皮层,膜和杏仁体的连接.
- 这项研究为使用dMRI的PD中MBI的神经结构相关物提供了新的见解.
相关概念视频
01:15Parkinson's Disease: Overview
537
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
537
01:24Parkinson's Disease: Treatment
264
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
264
01:37Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
01:30Attention-Deficit/Hyperactivity Disorder
56
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
56