门诊癌症患者静脉血栓栓塞的初级预防:最近的进展和实际影响
Amye M Harrigan1,2, Marc Carrier2,3, Tzu-Fei Wang4
1Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Polish archives of internal medicine
|April 25, 2024
概括
接受治疗的癌症患者面临着静脉血栓栓塞 (VTE) 的高风险. 使用阿皮克萨班或里瓦罗克萨班的初级血栓预防可能会降低高风险的门诊患者的静脉动脉突发症风险.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉血栓栓塞 (VTE) 是在接受抗癌治疗的门诊癌症患者中经常出现的并发症.
- 许多因素,包括患者,癌症和与治疗相关的因素,以及生物标志物,在癌症患者中增加了VTE风险.
研究的目的:
- 审查风险因素和评估门诊癌症患者的静脉瘤.
- 为了检查这种人群中初级血栓预防的作用.
- 概述启动初级血栓预防的实际考虑.
主要方法:
- 这篇叙述性综述综合了有关静脉瘤风险因素和癌症患者评估的现有文献.
- 它评估了使用直接口服抗凝剂进行初级血栓预防的随机对照试验的证据.
- 科拉纳评分被强调为一个关键的风险评估工具.
主要成果:
- 科拉纳评分有助于识别风险高的门诊癌症患者.
- 两项试验证明了阿皮克萨班和里瓦罗克萨班在降低中高风险患者静脉瘤风险方面的有效性.
- 初级血栓预防是预防静脉瘤的一个可行的策略.
结论:
- 通过Khorana得分识别的中高风险的门诊癌症患者可能受益于初级血栓预防.
- 像阿皮克萨班和里瓦罗克萨班这样的低剂量直接口服抗凝剂在VTE预防方面表现有前途.
- 仔细考虑实际方面对于实施血栓预防非常重要.
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