人类乳头瘤病毒相关的多种类型癌症:第一个 Vulval 病例的第一次描述
Charlotte C Currie1,2, Darren Leaning3, W Glenn McCluggage4
1Department of Cellular Pathology, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.
概括
这项研究报告了第一例与人乳头瘤病毒 (HPV) 相关的多表型阴道癌在阴道中的病例. 这些发现强调了在不寻常的部瘤中考虑唾液类型瘤的重要性.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 妇科瘤学 妇科瘤学
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的多现象型鼻癌是一种罕见的瘤.
- 这种瘤通常发生在鼻管中,与HPV有关,特别是33型.
- 此前,在鼻腔区域之外 (乳房) 仅报告了一例病例.
研究的目的:
- 报告第一例发生在阴道的HPV相关多类型鼻癌的病例.
- 描述这个阴道瘤的临床和组织学特征.
- 提高病理学家对腺类型瘤在阴道中的潜在可能性的认识.
主要方法:
- 阴道瘤的组织病理学检查.
- 免疫组织化学染色用于p16.
- HPV 基因型鉴定用于识别特定的 HPV 类型.
主要成果:
- 第一个与HPV相关的多种类型鼻癌的 vulval 病例是在一个47岁的患者身上发现的.
- 瘤呈现为高级癌瘤,具有基质细胞和导管形成,表现出p16免疫活性.
- HPV 基因型鉴定证实了高风险 HPV 型 16 的存在.
结论:
- 这一病例代表了与HPV相关的多种类型的鼻癌在阴部的初步报告,具体出现在巴托林腺区域.
- 这些发现强调了唾液腺类型瘤在部表现的趋势.
- 病理学家应将唾液类型的瘤纳入形态非典型的部瘤的差异诊断.
更多相关视频
相关概念视频
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K


