牛犊 rEF:牛犊肌肉功能障碍与减少的射出分数对所有原因死亡率的影响
Robert D McBane1, David Liedl1, Waldemar Wysokinski1
1Gonda Vascular Center, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
减少小腿肌肉喷射率 (CMP EF) 与更高的死亡率有关. 随着CMPEF降低,死亡风险显著增加,独立于静脉膜问题.
科学领域:
- 血管医学 血管医学
- 心血管生理学心血管生理学
- 临床结果研究研究
背景情况:
- 小牛肌肉 (CMP) 的射出分数 (EF) 是静脉功能的一个关键指标.
- 减少CMP EF可能与不良健康结果有关.
- 了解CMP EF和死亡率之间的关系对于患者管理至关重要.
研究的目的:
- 调查不同程度下降的小腿肌肉喷射分数 (CMP EF) 和全因死亡率之间的关联.
- 要确定静脉膜无能或临床静脉疾病的严重程度是否影响了这种关系.
主要方法:
- 追溯分析5913名接受静脉气囊造影的成年患者.
- 患者根据CMP EF分类为组.
- 使用卡普兰-梅尔分析和考克斯比例危险模型评估的死亡率,对共变量进行调整.
主要成果:
- 随着CMP EF (日志排名P≤.001) 的下降,死亡率显著增加.
- 死亡风险比率从EF40-49%的1.4 (95% CI,1.0至2.0) 增加到EF10-19%的2.4 (95% CI,1.7至3.3),而EF≥50%的风险比率增加到2.4 (95% CI,1.7至3.3).
- 临床静脉疾病 (CEAP) 评分预测死亡率,但静脉膜无能不能独立预测结果. 在调整后,CMP EF和CEAP得分仍然是死亡率的独立预测指标.
结论:
- 减少小腿肌肉喷射率是所有原因死亡率增加的独立预测因素.
- 死亡风险随着CMPEF逐渐下降而升级.
- 增加死亡率的机制似乎与肌肉生理有关,而不是静脉膜无能.
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