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相关概念视频

Cardiac Action Potential01:30

Cardiac Action Potential

1.4K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.4K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

3.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
3.8K
Electrocardiogram Fundamentals01:28

Electrocardiogram Fundamentals

572
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
572
Electrocardiogram01:29

Electrocardiogram

2.3K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.3K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

917
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
917
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

4.9K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
4.9K

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相关实验视频

Updated: Jun 27, 2025

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
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Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

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在重极化和导电异质之间,显著的电图特征和心室节律失常诱导模式.

Estelle Renard1, Elodie Surget1, Richard D Walton1

  • 1IHU LIRYC, L'Institut des maladies du RYthme Cardiaque, Fondation Bordeaux Université, Bordeaux, France; University of Bordeaux, Inserm, Centre de Recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.

JACC. Clinical electrophysiology
|April 25, 2024
PubMed
概括

局部电气异常是心室动和J波综合征的关键. 微观结构的变化,特别是通道阻断剂,显著影响电图和心律失常的脆弱性.

关键词:
这就是J波综合征.电图片的碎片化 电图片的碎片化异常发病的心室纤维化.突然的心脏病死亡.腹腔动脉动是一种心房动.

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Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
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Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

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Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
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科学领域:

  • 心脏电生理学 心脏电生理学
  • 节律失常的研究研究arrhythmogenesis.
  • 心血管药理学心血管药理学

背景情况:

  • 局部电气异常越来越多地被识别为异常性心室动和J波综合征.
  • 了解这些异常对于预测心律失常风险至关重要.

研究的目的:

  • 描述局部复极化和导电异质性的电信号.
  • 为了确定它们在心脏易受心律失常方面的作用.

主要方法:

  • 在猪心室中进行光学映射,诱导复极缩短 (pinacidil) 或导电减慢 (flecainide).
  • 当地表心组织的破坏被用来创造结构异质性.
  • 电图被记录下来,自发性/诱导性心律失常被量化.

主要成果:

  • 导电减速和结构异质性导致了电图的碎片化,特别是在flecainide.
  • 自发性心律失常随着复极缩短和导电减慢而增加.
  • 节律失常的脆弱性在导电减慢时最高,在复极缩短时最低.

结论:

  • 微结构基板显著影响电图,特别是与通道阻塞剂相结合时.
  • 局部动作潜能持续时间的缩短会增加自发性心律失常,但不会导致电图碎片化.