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怀孕期间母亲吸烟与青春期早期的DNA甲基化有关:一个兄弟姐妹比较设计

Nikolina Nonkovic¹, Kristine Marceau¹, John E McGeary²

¹Department of Human Development and Family Science, Purdue University.

Developmental psychology

|April 25, 2024

概括

怀孕期间母亲吸烟 (MSDP) 对 CNTNAP2,CYP1A1 和 MYO1G 等基因的后代DNA甲基化 (DNAm) 有影响. 这种表观遗传变化可能部分解释了MSDP和ADHD-HI症状之间的联系.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
发展心理学发展心理学
环境健康环境健康

背景情况:

怀孕期间母亲吸烟 (MSDP) 与后代的发育问题有关.
像AHRR和CYP1A1这样的基因的特定DNA甲基化 (DNAm) 变化与MSDP相关.
了解介导MSDP影响的生物途径至关重要.

研究的目的:

复制MSDP和DNAm之间的关联在中年童年-青春期使用兄弟姐妹不一致的设计.
检查DNAm在调解MSDP和注意力缺陷/多动障碍 (ADHD-HI) 症状之间关系中的作用.
为了隔离特定于儿童的MSDP对DNAm的影响,控制家族混.

主要方法:

跨截面兄弟姐妹比较设计,使用328个家庭对MSDP不一致.
量化儿童特异性MSDP暴露,以兄弟情侣为中心.
调整了产前和产后的共同变量,以及家族因素.

主要成果:

儿童特异性MSDP与全球DNAm和CNTNAP2,CYP1A1和MYO1G中的甲基化有关.
在CNTNAP2和MYO1G中的甲基化在一个测量上显示MSDP和ADHD-HI症状之间的部分调解.
这些发现支持从MSDP到DNAm.的潜在因果途径.

结论:

儿童特定的MSDP暴露影响后代DNAm,特别是在特定的基因中.
表观遗传变化可能部分调解MSDP和ADHD-HI症状之间的联系.
需要进一步的纵向和遗传研究来证实这些发现.

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