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Updated: Jun 27, 2025

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使用特定站点的结合系统构建用于CAR-T细胞治疗的开关模块

Tuersunayi Abudureheman1, Hang Zhou1,2, Li-Ting Yang1

  • 1Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Bioconjugate chemistry
|April 25, 2024
PubMed
概括

这项研究引入了一种新的双特异性安全开关模块,用于化学抗原受体T细胞 (CAR-T) 治疗. 这项创新提高了CAR-T细胞对各种瘤的疗效,并提高了治疗的安全性.

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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