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相关概念视频

Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
475
Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
287
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

761
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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试验疼痛的方法 试验疼痛的方法

Ann Jurecic

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    概括
    此摘要是机器生成的。

    当代文学,特别是散文,探讨了身体痛苦的体现经验. 尤拉·比斯 (Eula Biss) 和莱斯利·杰米森 (Leslie Jamison) 等作家的文章深入探讨了女性痛苦和社会反应的复杂性.

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    科学领域:

    • 文学研究是文学研究.
    • 医学人文学科 医学人文学科
    • 性别研究是关于性别的研究.

    背景情况:

    • 叙事分析传统上侧重于回忆录和虚构的疾病文学.
    • 当代作家越来越多地利用散文形式来探索体现的经验.
    • 法语动词"essayer" (尝试) 强调了这篇文章与不确定性的对抗性质.

    研究的目的:

    • 检查文学散文在描绘身体痛苦的体现经验中的作用.
    • 分析当代文章,特别是那些关注女性痛苦的文章.
    • 调查围绕女性痛苦的经历,解雇和社会反应的问题.

    主要方法:

    • 对当代文学散文的分析,包括欧拉·比斯 (Eula Biss) 的"疼痛尺度" (2005年) 和莱斯利·杰米森 (Leslie Jamison) 的"女性疼痛的大统一理论" (2014年).
    • 探索这些文章中使用的专题内容和叙事策略.
    • 探讨作者提出的关于疼痛和同情心的哲学和社会问题.

    主要成果:

    • 文学散文提供了一个独特而强大的媒介来传达体现的痛苦经验.
    • 比斯和詹姆森的文章批判性地解决了女性疼痛的减少和误解性质.
    • 这些作品突出了社会未能充分应对他人的痛苦的失败.

    结论:

    • 文章形式是理解疾病叙事的重要,但经常被忽视的类型.
    • 当代散文挑战社会对女性痛苦的看法和反应.
    • 对文章作为一种疾病写作方式的进一步研究是有必要的.