在非细菌性慢性囊炎和膀癌中PD-L1表达
Inga Kosova1,2, Vagan Barsegian3, Lyudmila Gundorova4
1Department of Urology and Surgical Andrology, Russian Medical Academy of Continuous Professional Education, 2/1, Bldg. 1, Barrikadnaya Street, 125993, Moscow, Russia.
International urogynecology journal
|April 25, 2024
概括
在非细菌性慢性囊炎 (NCC) 和膀癌 (BC) 患者中发现了PD-L1表达,BC患者的发病率更高. 在这两种情况下,PD-L1水平与病毒感染和膀炎症相关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 非细菌性慢性囊炎 (NCC) 和膀癌 (BC) 是影响膀的疾病.
- 编程死亡连接体1 (PD-L1) 是一种免疫检查点蛋白质,与各种癌症和炎症疾病有关.
- 了解NCC和BC中的PD-L1表达可能会提供有关疾病机制和潜在治疗点的见解.
研究的目的:
- 研究和比较非细菌性慢性囊炎 (NCC) 和膀癌 (BC) 患者的PD-L1表达.
- 探索PD-L1表达,病毒感染和NCC和BC的膀壁炎症程度之间的关联.
主要方法:
- 这项研究包括20名NCC患者和20名BC患者.
- 膀组织样本进行了炎症 (H&E染色),病毒病原体 (实时PCR) 和PD-L1表达 (免疫组织化学) 的分析.
- 进行了统计分析,以将PD-L1免疫细胞得分与临床和病理发现相关联.
主要成果:
- 在40%的NCC患者和85%的BC患者中检测到PD-L1表达.
- 病毒病原体,特别是爱斯坦-巴尔病毒 (EBV),在50%的NCC和60%的BC患者中被发现.
- 在NCC中,PD-L1得分与炎症,淋巴结合物,小细胞结合和病毒存在有很强的相关性. 在BC中,PD-L1得分与炎症和病毒存在相关.
结论:
- 在NCC患者的膀组织中表达PD-L1,尽管其表达率低于BC患者.
- 在NCC和BC中PD-L1表达的程度与病毒感染的存在和膀壁炎症的程度有关.
- 这些发现表明PD-L1在NCC和BC的炎症过程中可能发挥作用,可能受到病毒病因的影响.
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