咖啡,酒精和人工甜味剂与胃肠道症状有时间关联
Egbert Clevers1,2, Darren Launders3, Damian Helme3
1SkyGazer Labs Ltd, Cambridge, UK. e.clevers@waddinxveen.nl.
Digestive diseases and sciences
|April 25, 2024
概括
这项研究发现,咖啡,酒精和人工甜味剂经常与患有刺激性肠综合征 (IBS) 的人的胃肠症状有关. 一些食物与症状的关联会出现延迟发病,影响饮食管理策略.
科学领域:
- 胃肠病学 胃肠病学
- 饮食科学 饮食科学
- 临床营养学 临床营养学
背景情况:
- 刺激性肠综合征 (IBS) 管理涉及到针对脑肠相互作用,透效应,微生物发酵和免疫反应的多种饮食策略.
- 多种病理生理机制使得识别特定的食物触发器对许多IBS患者来说具有挑战性.
研究的目的:
- 调查和建立特定食物的消费和胃肠道症状的发生在一个大队列之间的关联.
- 分析大规模的,现实世界的饮食和症状数据,以揭示IBS的食物症状关系.
主要方法:
- 利用mySymptoms智能手机应用程序从用户那里收集匿名的食物摄入量和症状日记 (腹痛,腹,胀气,气体).
- 包括至少为期三周的日记,并使用专有算法来分析食物与症状的关联.
- 在匿名参与者中进行了一项应用程序范围的调查,以确认基于罗马四号标准的IBS诊断.
主要成果:
- 分析了9710份高质量的食物症状日记;70%的调查受访者符合IBS的罗马IV标准.
- 确定了咖啡因咖啡和腹 (1-2小时食后),酒精和多种症状 (4-72小时),人工甜味剂和多种症状 (24-72小时) 之间的强烈关联.
- 观察到胺丰富的食物与腹痛/腹之间的关联,并指出缺乏显著的FODMAP-症状关联,与现有文献相反.
结论:
- 在大量IBS患者中,含咖啡因的咖啡,酒精饮料和人工甜味剂与胃肠道症状有显著的关联.
- 症状的发作可能发生在饭后2小时内,但也注意到对某些食物的延迟反应,需要考虑饮食建议.
- 需要进行进一步的临床试验,以确定IBS管理中确定的食物症状关联的因果关系.
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