评估人环素对儿童淋巴瘤幸存者的心脏功能的影响 通过左心室肌肉工作对儿童淋巴瘤幸存者的心脏功能的影响
Yuqiong An1, Li Xue1, Liyuan Xu1
1Heart Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Pediatric cardiology
|April 25, 2024
概括
心肌工作 (MW) 能有效地检测早期左心室 (LV) 功能障碍在儿童癌症幸存者接受治疗的Anthracyclines,优于传统心声回声学. 这种敏感的方法有助于早期干预化疗引起的心脏问题.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 儿科 儿科 儿科
背景情况:
- 抗环素化疗可以导致左心室 (LV) 功能障碍.
- 传统的心声回声扫描通常无法检测儿童癌症幸存者 (CCS) 中的亚临床心脏功能障碍.
- 在CCS中回声心脏成像的实用性需要进一步建立.
研究的目的:
- 用心肌工作 (MW) 评估人类环素对儿童淋巴瘤幸存者的LV功能早期影响.
- 探索MW在检测化疗引起的心脏功能障碍中的临床应用价值.
- 与传统心声回声相比,评估MW的灵敏度.
主要方法:
- 51名儿童淋巴瘤幸存者在基线,第3次和第6次化疗周期进行了心声扫描.
- 测量了传统的心声回声学参数,LV全球纵向应变 (GLS) 和全球心肌工作 (GMW) 参数.
- 统计分析,包括相关性分析,用于比较参数并确定关系.
主要成果:
- 化疗后没有观察到LVEF或常规参数的显著变化,除了增加LV横向E/E外.
- 全球劳动指数 (GLS),全球建设性劳动和全球劳动效率均大幅下降.
- 全球浪费工作显著增加,GLS与GMW参数有很强的相关性 (P<0.001).
结论:
- 心肌工作 (MW) 是一种敏感的,非侵入性的心声回声学方法,用于量化评估儿童淋巴瘤幸存者的LV功能.
- 通过MW,可以在安赛克林化疗后检测出早期的左心室功能障碍.
- 这种模式为儿童癌症患者的心脏毒性监测和管理提供了宝贵的工具.
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