在老年西班牙裔/拉丁裔与人类免疫缺陷病毒感染者中代谢综合征和神经认知功能的差异
María J Marquine1,2,3,4,5, Lily Kamalyan1,6, Zvinka Z Zlatar2
1HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA.
AIDS patient care and STDs
|April 25, 2024
概括
艾滋病毒感染的西班牙裔个人经历了更糟糕的神经认知功能,而代谢综合征 (Met) 虽然更普遍,但它并不存在.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 神经认知障碍和代谢综合征 (MetS) 在艾滋病毒感染者 (PWH) 中很常见.
- 在老年PWH中存在神经认知功能的种族差异.
- 气象学在这些差异中的作用需要进一步研究.
研究的目的:
- 为了检查西班牙裔和非西班牙裔白人老年PWH之间的神经认知功能差异.
- 调查MetS在解释这些神经认知差异中的作用.
- 确定干预目标,以改善PWH中神经认知功能.
主要方法:
- 在加利福尼亚州南部,对116名50至75岁的社区居民进行了队列研究.
- 使用10项认知测试的电池评估神经认知功能,对人口统计学进行调整的全球分数.
- 使用标准标准确定MetS;共变量包括社会人口统计学,精神病,物质使用和艾滋病毒疾病特征.
主要成果:
- 与非西班牙裔白人PWH相比,西班牙裔PWH的整体神经认知功能更差 (科恩d = 0.56,p < 0.05).
- 西班牙裔PWH的MetS发病率更高 (56%对38%,p <0.05).
- 西班牙裔种族 (B = -3.39,p = 0.01) 和MetS (B = -2.73,p = 0.04) 独立地与更差的神经认知相关.
结论:
- 增加的MetS与老年PWH的神经认知功能恶化有关,不论种族.
- MetS无法解释西班牙裔和非西班牙裔白人PWH之间观察到的神经认知差异.
- MetS是旨在改善不同老年PWH人群神经认知结果的干预措施的关键目标.
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