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Updated: Jun 27, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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作为神经母细胞瘤中治疗点的MYCN 5' UTR

Marina P Volegova1, Lauren E Brown2, Ushashi Banerjee1

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Cell reports
|April 25, 2024
PubMed
概括

针对MYCN放大神经母细胞瘤,研究人员用CMLD012824.4抑制了真核细胞翻译启动因子4A1 (eIF4A1). 这种药物减少了瘤的生长,没有毒性,显示治疗潜力.

关键词:
CP: 癌症 癌症 癌症科普:分子生物学 分子生物学这就是MYCNCN.在MYCN放大后的放大.帕-克里普 (PAR-CLIP) 是一个阿米迪诺 - 洛卡格拉酸盐eIF4A1 的意思是神经母细胞瘤的神经母细胞瘤核糖体造型分析是指核糖体造型.洛卡格莱特酸盐的使用方法翻译翻译翻译翻译翻译翻译翻译法规 翻译法规

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