视网膜关利酸环酶激活蛋白5 (GCAP5) 的NMR结构,具有R22A突变,可消除二分化并增强环酶激活

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Diana L Cudia1, Effibe O Ahoulou1, Aritra Bej1

  • 1Department of Chemistry, University of California, Davis, Davis, California 95616, United States.

Biochemistry
|April 25, 2024
PubMed
概括

斑马鱼光受体中的酸环酸激活蛋白-5 (GCAP5) 的突变破坏了二分化,导致视网膜酸环酸 (GC-E) 的增强激活. 这种结构变化改变了结合,增加了GC-E亲和力,解释了活性增加.

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