在美国,母亲的红细胞与免疫接种率
Ronan P Sugrue1, Kenneth J Moise2, Jerome J Federspiel1
1Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC.
Blood advances
|April 25, 2024
概括
孕产妇的合免疫接种影响了美国1.5%的怀孕,高风险的红细胞 (RBC) 抗体从2010-2021年增加. 需要采取新的举措来减少这种发生率,并预防胎儿和新生儿 (HDFN) 的血液溶解性疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 产科和妇科 产科和妇科
- 输血医学 输血医学
背景情况:
- 胎儿和新生儿血液溶解性疾病 (HDFN) 是一种严重的疾病,由母亲对红细胞 (RBC) 抗原的异免疫接种引起.
- 美国缺乏关于孕产妇同免疫接种率的国家数据.
研究的目的:
- 描述美国各地怀孕中RBC与免疫接种的流行和趋势.
- 确定高风险红细胞抗体的类型和发病率,这些抗体有助于HDFN.
主要方法:
- 2010-2021年大型全国商业实验室数据库的分析.
- 包括近1000万例怀孕,并提供收集年份和居住状态.
- 使用CDC活产估计和按年加权的数据规范化和美国人口普查部门.
主要成果:
- 估计1.5%的怀孕被查为红细胞抗体呈阳性.
- 抗D抗体是最常见的 (64.1%),其次是抗K (10.7%) 和抗c (4.8%).
- 三种高危抗体 (抗D,抗K,抗C) 的发病率从2010年到2021年显著增加.
结论:
- 孕产妇的红细胞同免疫是一个重大问题,十年来高风险抗体的显着增加.
- 尽管在解释反D流行率方面存在挑战,但它仍然是HDFN的一个关键因素.
- 迫切需要制定新的倡议,以减少生育年龄妇女的免疫接种率.
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