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用甲福明治疗的糖尿病患者的维生素B12缺乏:一个横截面研究

Dat Tan Huynh¹, Ngoc Thi Nguyen², Minh Duc Do³

¹Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

|April 25, 2024

概括

在2型糖尿病中使用甲胺与维生素B12缺乏有关,影响了18.6%的越南患者. 长期使用和较高剂量增加了缺乏症的风险,需要定期查.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
营养科学营养科学

背景情况:

甲胺是2型糖尿病的主要治疗方法,以其安全性和有效性而闻名.
甲福明治疗的一个显著的副作用是维生素B12缺乏的可能性.
在接受甲福明治疗的患者中,了解维生素B12缺乏的患病率和危险因素对于患者的护理至关重要.

研究的目的:

为了确定越南2型糖尿病患者使用甲福林的维生素B12缺乏率.
为了确定与甲福林诱导的维生素B12缺乏相关的临床和人口因素.

主要方法:

在Vinmec中央公园医院进行了一项横截面研究.
从参与者那里收集了临床数据,甲福林使用细节和维生素B12 /叶酸盐水平.
统计分析,包括赔率比率 (OR) 和95%置信区间 (CI),用于评估关联.

主要成果:

在被研究的患者中,维生素B12缺乏的患病率为18.6%.
糖尿病的持续时间,甲福林使用的持续时间,甲福林剂量和血红蛋白水平最初与缺乏症有关.
在对共变量进行调整后,较高的甲福明剂量 (OR = 4.10) 和长期使用高剂量 (OR = 5.25) 显著增加了维生素B12缺乏症的风险.

结论:

维生素B12缺乏症在越南2型糖尿病患者中普遍存在,这些患者接受了美特福林治疗.
长期使用甲胺 (≥48个月) 和高剂量甲胺 (≥1000毫克/天) 是显著的危险因素.
对于长期接受高剂量甲福林治疗的患者,建议定期查维生素B12缺乏症.

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