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Updated: Jun 27, 2025

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Quantitative Analysis of Chromatin Proteomes in Disease
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蛋白质组学,人类环境暴露和心脏代谢风险
Andrew S Perry1, Kai Zhang2, Venkatesh L Murthy3
1Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN (A.S.P., S.Z., J.J.C., R.V.S.).
Circulation research
|April 25, 2024
概括
环境暴露与循环蛋白有关,这些蛋白质表明心血管和呼吸系统疾病的风险. 这种炎症代谢蛋白质突出显示了容易患心脏代谢疾病和不良健康结果的个体.
科学领域:
- 环境健康 环境健康
- 蛋白质组学是指蛋白质组学.
- 心血管流行病学心血管流行病学
背景情况:
- 将环境暴露与心血管疾病联系在一起的机制尚未完全理解.
- 识别循环中的蛋白质组签名可以阐明这些联系.
- 观察性队列研究对于检查这些关联至关重要.
研究的目的:
- 为了识别与环境暴露相关的循环蛋白质组签名.
- 调查这些蛋白质组特征与心脏代谢/呼吸系统疾病之间的关系.
- 探索蛋白质组特征对心血管疾病和死亡率的预测价值.
主要方法:
- 在CARDIA研究中 (约3000名参与者) 使用了惩罚和普通线性回归来测试>6500种蛋白质和29种环境暴露之间的关联.
- 在弗雷明汉心脏研究 (FHS) 和杰克逊心脏研究 (JHS) (>3500名参与者) 中使用了考克斯模型来评估环境蛋白质体特征与心血管疾病和死亡率的潜在关系.
- 包括建筑环境,绿地,空气污染,温度和社会脆弱性指标等环境因素.
主要成果:
- 蛋白质组签名揭示了新的/已确定的与心血管疾病相关的途径,包括DNA损伤,纤维化,炎症和线粒体功能.
- 环境蛋白质特征与心脏代谢疾病和呼吸系统表型 (例如,BMI,脂质,左心室质量) 在CARDIA中广泛相关,在FHS/JHS中复制.
- 社会脆弱性的蛋白质特征与心血管疾病和死亡率的风险增加有显著的关联,独立于临床风险因素.
结论:
- 环境暴露与炎症代谢蛋白质相关.
- 这种蛋白质组可以识别患心脏代谢疾病和呼吸系统表型/结果风险较高的个体.
- 需要进一步的研究来了解环境因素对心脏代谢健康的动态影响.
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