perfluoroalkyl/Polyfluoroalkyl 物质:与心血管疾病风险的联系
Jennifer J Schlezinger1, Noyan Gokce2
1Department of Environmental Health, Boston University School of Public Health, Boston, MA (J.J.S.).
Circulation research
|April 25, 2024
概括
perfluoroalkyl和 polyfluoroalkyl物质 (PFAS) 是广泛存在的环境毒素,与心血管疾病有关. 研究表明,PFAS暴露与除失脂症之外的多种心脏风险因素有关.
科学领域:
- 环境健康 环境健康
- 心血管疾病流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 心血管疾病 (CVD) 是全球主要的健康负担,环境因素对其有重大影响.
- perfluoroalkyl和 polyfluoroalkyl物质 (PFAS) 是由于工业和消费者广泛使用而在全球发现的持久性人造化学物质.
- 人类对PFAS的无处不在暴露是一个越来越令人担忧的问题,需要对其健康影响进行调查.
研究的目的:
- 审查连接国家科学,工程和医学院的流行病学证据,确定PFAS与心血管疾病风险因素.
- 探索PFAS暴露和血管疾病,包括动脉样硬化之间的潜在关联.
- 综合当前的理解,并确定有关PFAS和心血管健康的研究差距.
主要方法:
- 对调查PFAS暴露和心血管风险因素的流行病学研究进行系统审查.
- 分析了有关特定PFAS与疾病如失脂症,肥胖,高血压和高尿血症之间的关联的数据.
- 检查PFAS与血管疾病和动脉样硬化相关的证据.
主要成果:
- 有令人信服的证据支持PFAS暴露与失脂症之间存在关联.
- 观察数据表明PFAS和其他心血管风险因素之间存在联系,包括超重/肥胖,葡萄糖不耐受,高血压和高尿血.
- 现有研究表明,PFAS与血管疾病和动脉样硬化之间存在潜在的联系.
结论:
- 暴露于PFAS与多种心血管疾病的风险因素有关,这些风险因素超出了脂质障碍症.
- 虽然观测数据是支持性的,但需要进一步的研究来确定因果关系和阐明机制.
- 了解PFAS对心血管健康的全部影响对于公共卫生和监管行动至关重要.
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