暴露于重金属和心血管疾病
Ziwei Pan1,2, Tingyu Gong3, Ping Liang1,2
1Key Laboratory of Combined Multi Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China (Z.P., P.L.).
环境中的有毒重金属带来了显著的心血管疾病风险. 暴露会导致高血压和动脉样硬化,但预防和抗氧化剂等治疗可以减轻这些危险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 心血管医学 心血管医学
背景情况:
- 重金属 (,,,,) 是普遍存在的环境污染物.
- 越来越多的证据将重金属暴露与不良的心血管健康结果联系在一起.
研究的目的:
- 总结重金属对心血管健康的有害影响.
- 突出重金属诱导心血管损伤的机制.
- 讨论潜在的预防和治疗策略.
主要方法:
- 流行病学,基础和临床研究的审查.
- 分析涉及重金属毒性的病理生理路径.
- 预防和治疗干预措施的评估.
主要成果:
- 重金属诱导氧化应激,炎症和内皮功能障碍.
- 暴露会破坏脂质代谢,离子稳态和表观遗传调节.
- 长期暴露会增加高血压,心律失常和动脉样硬化的风险.
结论:
- 接触重金属是心血管疾病的重要危险因素.
- 诸如化和抗氧化剂 (维生素,β-胡卜素) 等公共卫生措施和干预措施可以减少心血管疾病的负担.
- 和等矿物质可能起到保护作用.
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