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离子AIE光敏剂的捐赠器-接受器调制,用于增强ROS生成和NIR-II发射

Xueqin Yang^1,2, Xinyuan Wang^1,3, Xun Zhang³

¹Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Mechanical and Aerospace Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Advanced materials (Deerfield Beach, Fla.)

|April 25, 2024

概括

离子聚合诱导排放 (AIE) 光敏剂是为增强光动力学疗法 (PDT) 设计的. 这些新型的AIE光敏感剂在NIR-II窗口中发射,改善癌细胞切除和体内瘤治疗学.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
摄影化学的使用.

背景情况:

聚合诱导排放 (AIE) 光敏剂在生物成像和治疗方面表现有前途.
限制包括短发射波长和非特异性有机细胞向,阻碍治疗疗效.

研究的目的:

开发具有第二近红外 (NIR-II) 窗口发射的新型离子AIE光敏感剂.
为了增强光动力学治疗 (PDT) 的结果,并改善细胞/器官向.

主要方法:

采用了使用dithieno[3,2-b:2',3'-d]pyrrole (DTP) 作为捐赠物和 (In) 作为接受物的捐赠者-受体调制策略.
构建了离子AIE光敏感剂 (DTP-In),并研究了它们的光物理特性,ROS生成和自组装成纳米聚合物.
评估细胞吸收,线粒体向和癌细胞的体外/体内光动力学除.

主要成果:

合成了DTP-In,由于强烈的捐赠者-受体相互作用,呈现红移吸收和NIR-II发射.
与传统纳米颗粒相比,DTP-In纳米聚合物显示出增强的细胞吸收和特定的线粒体向.
在660nm激光照射下实现了4T1癌细胞的高效光动力学除和有效的体内瘤治疗学.

结论:

捐赠者-接受者AIE光敏感剂的分子工程可以实现NIR-II发射和提高PDT疗效.
离子AIE纳米聚合物提供卓越的细胞吸收和向,用于增强癌症治疗.
这种方法有助于开发癌症治疗的先进的治疗术策略.

关键词:

聚合引发的排放量聚合引发的排放量捐赠者接受者调节调节针对线粒体的目标接近红外线的辐射.光动力学疗法是一种光动力学疗法.

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Photosystem II

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Photosystem I

Photosystem I

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