环境紫外B辐射,补充剂和其他因素相互作用,根据种族而不同地影响维生素D状态:一个横截面研究
Margaret M Brennan1, Jos van Geffen2, Michiel van Weele2
1Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, D24 DH74 Dublin, Ireland.
Clinical nutrition (Edinburgh, Scotland)
|April 25, 2024
概括
维生素D缺乏是很常见的,特别是在非白人个体. 精确测量紫外B (UVB) 辐射并考虑相互作用,可以改善维生素D (25(OH) D的预测和个性化.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 环境健康 环境健康
背景情况:
- 尽管已知决定因素,但维生素D缺乏仍然很普遍.
- 目前的补充指南往往是一般化的.
- 需要更好地了解维生素D状态预测因子.
研究的目的:
- 研究环境紫外B (UVB) 辐射在预测维生素D状态中的作用.
- 探索UVB,种族和其他因素与维生素D水平之间的相互作用.
- 推进维生素D预测模型,超越一种适合所有人的方法.
主要方法:
- 利用了来自438,978名参与者的英国生物库数据 (亚洲人,黑人,白人).
- 将住宅UVB数据 (热层辐射监测互联网服务) 链接到参与者.
- 计算累积和加权UVB (CW-D-UVB) 并评估与25(OH) D的关联,使用多变量回归与相互作用,按种族分层.
主要成果:
- 观察到中位数25OH) D水平的显著种族差异 (白人>黑人>亚洲人).
- 在所有种族中,CW-D-UVB是25~OH) D的强有力的预测因素.
- 补充是亚洲和黑人参与者的主要预测因素,而CW-D-UVB是白人参与者的关键因素.
- 确定了涉及BMI,性别,年龄和CW-D-UVB补充剂的显著相互作用,因种族而异.
结论:
- 维生素D缺乏是普遍存在的,不成比例地影响非白人人口.
- 环境UVB是25OHD的重要预测因子,其影响受到各种因素的调节.
- 精确的UVB测量和对相互作用的考虑可以提高25(OH) D预测,并支持个性化维生素D优化策略.
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