光降解增强了 antracen 在皮肤上的有毒作用
Molly Brzezinski1, Leisha Martin1, Kayla Simpson1
1Department of Life Sciences, College of Science, Texas A&M University - Corpus Christi, Corpus Christi, TX, USA.
Journal of hazardous materials
|April 25, 2024
概括
常见的污染物 antracen 的光降解增加了它对皮肤细胞和无毛小鼠的毒性. 这些改变的产品模仿炎症性皮肤疾病,突出显示阳光暴露的多环芳 (PAHs) 的风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 皮肤病学 皮肤病学
背景情况:
- 炭是一种多环芳 (PAH) 和环境污染物,与皮肤疾病有关.
- 光降解可以改变烯,可能增加其毒性,并产生有害的副产品,如9,10-氨酸和酸.
研究的目的:
- 评估烯的光降解如何影响其对皮肤的毒性.
- 阐明这些皮肤毒性变化背后的机制.
主要方法:
- 暴露在阳光下,以降解和识别产品.
- 在人类角质细胞培养物 (2D和3D) 上应用烯及其光降解产品.
- 在无毛小鼠皮肤上进行局部分娩研究.
主要成果:
- 光降解的烯显著降低了细胞活力和分化,而非降解的烯则延迟了细胞迁移.
- 光降解产品调节上升的炎症基因 (例如,il1a,il1b,il8,mmp1) 和调节下降的其他基因 (例如,tlr4).
- 在小鼠中,光降解的素导致表皮厚化,增加皮肤细胞性,并抑制Connexin-43的产生,模仿炎症性皮肤状况.
结论:
- 光降解增强了 antracen 对皮肤的毒性.
- 炭烯光降解产品表现出类似于亚托皮炎,接触性皮炎,湿疹和牛皮所见的特性.
- 暴露于PAHs如 antracen,特别是在阳光下,造成皮肤刺激和炎症性皮肤疾病的显著风险.
更多相关视频
12:37Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
18.2K
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
1.9K
相关概念视频
Mutations
37.0K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
37.0K
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Pigmentation
2.4K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.4K
Nucleotide Excision Repair
3.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
The Antenna Complex
6.0K
Plants and other photosynthetic organisms comprise pigments capable of absorption of direct sunlight. These pigments are present in the reaction center - the main site of photochemical reactions as well as in the antenna complex. Under average light conditions, the rate at which reaction center pigments absorb light is far below the electron transport chain's capacity. As a result, the reaction center alone cannot provide enough energy to drive photosynthesis. The photosynthetic efficiency...
6.0K
Photoreceptors and Plant Responses to Light
20.3K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
20.3K
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)