空气污染混合物与过敏鼻炎患者的氧化应激恶化和症状恶化有关:来自小组研究的证据
Jinhui Li1, Haisheng Wu2, Weiwei Xing3
1Department of Urology, Stanford University Medical Center, Stanford, CA, USA.
The Science of the total environment
|April 25, 2024
概括
短期暴露于PM2.5,O3和SO2等空气污染物会通过增加氧化应激和鼻症状,加剧过敏性鼻炎 (AR). 这项研究强调了污染物混合物对AR患者健康和生活质量的综合有害影响.
科学领域:
- 环境健康 环境健康
- 过敏学 过敏学
- 毒理学 毒理学 毒理学
背景情况:
- 过敏性鼻炎 (AR) 的患病率正在全球范围内增加.
- 环境污染物被怀疑是AR的贡献者,但机制尚不清楚.
- 了解污染物对AR的影响对于公共卫生至关重要.
研究的目的:
- 评估短期暴露于环境空气污染物对AR患者氧化应激,症状和生活质量的影响.
- 为了确定污染物混合物 (PM2.5,O3,SO2,NO2) 的单个和组合影响.
- 确定关键的污染物对AR的不良健康结果的贡献者.
主要方法:
- 在一年内对49名AR患者进行小组研究,并进行了四次重复评估.
- 对PM2.5,O3,SO2和NO2的个人暴露量.
- 通过鼻水评估氧化应激生物标志物 (MDA,SOD) 和患者报告的结果 (SRS,VAS,RQLQ).
- 使用贝叶斯核机器回归 (BKMR) 进行联合效应分析.
主要成果:
- 在污染物混合物 (处于或高于中位数) 和氧化应激增加 (MDA升高,SOD降低) 之间发现了显著的关联.
- 污染物混合物对AR症状产生了有害影响,与增加的SRS得分密切相关.
- 在太原市,PM2.5,O3和SO2被确定为对不良影响的主要贡献者.
结论:
- 对空气污染物混合物的短期暴露显著增加了AR患者的氧化应激和鼻腔症状.
- 污染物混合物通过氧化应激和降低抗氧化能力对AR患者的生活质量产生负面影响.
- 需要进一步的研究,以充分阐明这些不良影响背后的机制.
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