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相关概念视频

Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

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Formulations for Freeze-drying of Bacteria and Their Influence on Cell Survival
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优化冷化初级干燥:用实验和建模技术进行疫苗病例研究.

Jeff Najarian1, Efimia Metsi-Guckel1, Harshil K Renawala1

  • 1Merck & Co., Inc., Rahway, NJ 07065, USA.

International journal of pharmaceutics
|April 25, 2024
PubMed
概括

优化疫苗的冷化周期涉及积极的干燥,挑战传统方法. 这项研究发现,超过崩温度 (Tc) 可以安全地减少45%的干燥时间,同时保持疫苗质量.

关键词:
崩的崩是什么意思干燥层的阻力 干燥层的阻力冷干燥显微镜的使用方法软化液化化是什么意思建模建模模型是什么主要干燥主要干燥

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科学领域:

  • 制药科学 制药科学
  • 化学工程是化学工程的重要组成部分.
  • 生物技术是生物技术.

背景情况:

  • 化 (冷干燥) 对于疫苗的稳定性和保质期至关重要.
  • 优化初级干燥时间是减少整体冷化周期长度的关键.
  • 传统的方法往往导致低于最佳的,漫长的干燥周期.

研究的目的:

  • 为了优化疫苗配方的初级干燥时间.
  • 评估热特性,温度概况和关键质量属性 (CQA).
  • 开发一种更可靠的方法来确定瓶子中的宏观崩温度.

主要方法:

  • 差分扫描热量计 (DSC) 和冷干燥显微镜 (FDM) 用于确定关键温度 (Tg',Tc).
  • 人度温度测量 (MTM) 用于评估产品的电阻 (Rp) 和温度配置文件.
  • 热量和质量转移的第一原则建模,以产生初级干燥设计空间.

主要成果:

  • 过度干燥条件超过FDM确定的崩温度 (Tc),在不影响CQAs的情况下,干燥时间减少了45%左右.
  • 产品初级干燥后的温度下降与宏观崩的程度相关.
  • 通过对温度,电阻和视觉蛋糕外观进行定量分析,确定了更具代表性的宏观崩温度 (Tcm).

结论:

  • 精确确定瓶子中的宏观崩对于流程优化至关重要.
  • 根据特定的产品特性进行激烈的冷化干燥,可以显著减少循环时间.
  • 将实验数据与建模技术相结合,可以有效开发和优化冷化过程.