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识别敏感的终点,以评估酸盐诱导的生殖和发育毒性:文献挖掘研究的研究

Kai Li1, Yiping Zhang1, Ludi Li1

  • 1Department of Toxicology, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|April 25, 2024
PubMed
概括

暴露于二甲基甲酸 (DBP) 和二甲基甲酸 (DEHP) 可能会影响后代的生殖健康. 这项研究确定了敏感的终点,并建立了用于甲酸盐风险评估的新参考剂量 (RfD).

关键词:
一个亲生关系的距离.DBP DBP DBP 的意思是说.在DEHP中,DEHP是DEHP.参考剂量是指参考剂量.总精子数量 总精子数量

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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