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一个全面的 bupleuri radix 和其生物活性成分的综述:主要关注治疗慢性肝病
Ying Zhong1, Jianchao Li2, Xiaomin Zhu1
1The Second Hospital of Shandong University, 247 Beiyuan Ave, Jinan, Shandong, 250033, China.
Journal of ethnopharmacology
|April 25, 2024
概括
布普勒里根 (Bupleuri Radix,BR) 是一种传统的中医药,有效治疗肝炎和肝硬化等肝脏疾病. 对其化合物和机制的未来研究将有助于开发新的肝疗法.
科学领域:
- 草药是一种草药.
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 布普勒里根 (Bupleuri Radix,BR) 是一种长期用于治疗肝脏抑郁症的草药.
- 现代研究强调了BR的抗炎,免疫调节,代谢和抗癌性质,用于肝脏疾病.
- 肝炎,脂肪肝炎,肝硬化和肝癌是全球重要的健康问题,缺乏关于BR作用的全面审查.
研究的目的:
- 系统地审查古典中医药处方和用于治疗肝脏疾病的BR成分.
- 阐明BR在肝病管理中的作用机制.
- 为未来基于BR的治疗方法的研究和开发提供参考.
主要方法:
- 在PubMed,Wiley,Springer,Google Scholar,Web of Science和CNKI搜索了过去三十年来关于BR及其处方的文献.
- 整理和总结了关于BR的经典处方,活性成分和治疗肝脏疾病的机制的信息.
主要成果:
- BR及其经典处方 (例如,Xiao Chai Hu,Da Chai Hu) 历来用于肝炎,脂肪肝炎,肝硬化和肝癌.
- 关键的生物活性成分包括赛可索,多糖,黄,固醇和有机酸.
- 这些化合物具有抗炎,抗氧化,免疫调节和脂质调节作用,但通过CYP450和氧化应激的潜在肝毒性需要谨慎.
结论:
- BR,其化合物和相关的传统中医药配方在治疗肝脏疾病方面表现出多目标,多途径的有效性.
- 对BR及其生物活性成分进行进一步的药理和毒理研究对于发现新的肝疗法至关重要.
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