血小板分布宽度与美国成年人全因和因特定死亡率的关联
1Department of Medicine, Eastern Virginia Medical School, Norfolk, USA; Department of Pulmonary Disease, Amsterdam University Medical Center, Amsterdam, the Netherlands.
International journal of cardiology
|April 25, 2024
概括
血小板分布宽度 (PDW) 预测死亡风险. 较高的PDW与在前5年内增加全因,心血管和癌症死亡率有关,这突显了其预后价值.
科学领域:
- 血液学 血液学 血液学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 血小板分布宽度 (PDW) 反映了循环血小板大小的变化.
- 之前关于PDW和死亡率的研究受到小样本大小的限制.
- 这项研究调查了PDW与死亡率的关联,在一个大型的代表性队列中.
研究的目的:
- 检查PDW和全因死亡率之间的关系.
- 评估PDW与特定原因死亡率的关联,包括心血管和癌症死亡.
主要方法:
- 使用了来自国家健康和营养检查调查III (NHANES III) 的数据,与死亡记录联系在一起.
- 不包括18岁以下的参与者以及有心肌梗塞病史的人.
- 采用5年时间间隔的克斯模型,以多重共变量进行调整,因为违反了比例性假设.
主要成果:
- 该队列包括15688名参与者,在随访期间 (长达31年) 死亡率为40.6%.
- 升高的PDW与0-5年 (HR=1.44) 和5-10年 (HR=1.23) 内的全因死亡率显著相关.
- PDW还显示了与心血管死亡率 (0-5年,HR=1.58),癌症死亡率 (0-5年,HR=1.48),其他原因死亡率 (0-5年,HR=1.35;5-10年,HR=1.38) 的显著关联.
结论:
- 血小板分布宽度 (PDW) 作为一个独立的,时间依赖的死亡率预测指标.
- 对所有原因,心血管,癌症和其他原因的死亡率在基线后5年内观察到显著的关联.
- 需要进一步的研究来阐明推动这种关联的潜在机制.
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