大麻醇破坏了人体术语胎盘中托的代谢
Ramon Portillo1, Cilia Abad1, Tetiana Synova1
1Department of Pharmacology and Toxicology, Charles University, Faculty of Pharmacy in Hradec Kralove, Czech Republic.
大麻醇 (CBD) 改变了人类胎盘中的酸盐代谢,影响胎儿的神经发育. 这项研究表明,CBD破坏了对怀孕至关重要的血清激素和 kynurenine 途径.
科学领域:
- 产科和妇科 产科和妇科
- 发育生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 怀孕期间大麻的使用量正在增加,这引发了对胎儿发育的担忧.
- 大麻化合物大麻 (CBD) 具有治疗潜力,但其对怀孕的影响尚不清楚.
- 通过血清素和 kynurenine 途径的托芬 (TRP) 代谢对于胎儿神经发育至关重要.
研究的目的:
- 研究CBD对人类胎盘中托代谢的影响.
- 检查CBD对关键酶和TRP通路中的代谢物释放的影响.
- 评估CBD对胎盘血清素吸收的影响.
主要方法:
- 利用人类术语状胎盘扩张物作为一个ex vivo模型.
- 评估TRP代谢酶的基因和蛋白质表达.
- 使用微膜 (MVM) 囊泡来测量血清的传输.
主要成果:
- CBD改变了关键TRP代谢酶的基因和蛋白质表达,包括TPH,MAO-A,IDO-1,KMO和KAT-1.
- CBD可将胎盘血清的摄取量降低高达60%,并改变了代谢物水平.
- CBD促进了TRP的新陈代谢向金氨酸通路,上调IDO-1和KMO,并降低KAT-1的调节.
结论:
- CBD显著调节了人类胎盘中的托芬代谢.
- 在怀孕期间,CBD的作用可能会扰乱血清素和 kynurenine 途径的关键平衡.
- 需要进一步的研究来了解对胎儿神经发育的影响.
更多相关视频
12:17The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
08:08Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Factors Affecting Drug Distribution: Physiological Barriers
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Teratogenicity
Tissue-Drug Binding: Localization of Drugs and its Significance
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...
