生活不同阶段的体力活动及其对初始免疫接种和对COVID-19的炎症反应的影响
Priscila Almeida Queiroz Rossi1,2, Regis Gomes3, Teresa Cristina do Nascimento Salazar1,2
1Postgraduation Student in Science and Health, Federal University of Piaui, Teresina, PI, Brazil.
Journal of physical activity & health
|April 25, 2024
概括
青少年身体活动 (PA) 和当前中度至强度PA (MVPA) 实践增强抗体产生和对COVID-19疫苗接种的免疫反应. 定期炼,尤其是在青春期,可以提高疫苗的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 运动科学 运动科学
背景情况:
- 以前的体力活动 (PA) 可能会影响免疫对疫苗的反应.
- 了解儿童,青少年和当前PA对COVID-19疫苗疗效的影响至关重要.
研究的目的:
- 评估过去和现在的体力活动水平如何影响COVID-19疫苗接种后的抗体产生和炎症标志物.
- 为了确定青少年PA或当前MVPA是否影响疫苗诱导的免疫反应.
主要方法:
- 血液样本分析了抗SARS-CoV-2 IgG抗体和细胞因子.
- 过去的PA (童年,青春期) 自报;目前的PA通过IPAQ进行评估.
- 在第一剂和第二剂COVID-19疫苗接种之间评估了115名参与者.
主要成果:
- 青少年PA与成人抗体产生增加有显著的相关性 (P=.025).
- 较高的当前MVPA (≥150分钟/周) 与较大的抗体反应相关 (P=.046).
- 青少年PA实践者显示G-CSF,IL-17,IL-1RA,IL-1β和IL-2的水平升高.
结论:
- 在青春期练习PA可以改善COVID-19疫苗接种后的抗体生产.
- 累积≥150分钟/周的MVPA增强了对COVID-19疫苗的免疫反应.
- 特别是在青春期,PA有助于对疫苗接种产生更强大的免疫反应.
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