在COVID-19患者中使用胸部CT测量肺体积测量:一项在日本的队列研究
Shiro Otake1, Yusuke Shiraishi2, Shotaro Chubachi3
1ivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
BMJ open respiratory research
|April 25, 2024
概括
较低的计算机断层扫描 (CT) 肺部体积在COVID-19患者中预测了关键的结果和并发症. 在CT扫描中,肺总容量 (TLC) 降低表明严重疾病的风险更高,恢复速度更慢.
科学领域:
- 放射学和成像学 放射学和成像学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 感染可能导致严重的呼吸道损害和长期并发症.
- 准确的预后标记对于治疗住院COVID-19患者至关重要.
- 计算机断层扫描 (CT) 是评估COVID-19肺部参与的关键成像方式.
研究的目的:
- 评估CT计量肺体积对COVID-19患者关键结果的预测值.
- 研究CT衍生肺体积与住院后并发症之间的关联.
- 为了确定COVID-19后残余肺体积损失的预后因素.
主要方法:
- 在1200名住院COVID-19患者的回顾性队列研究中.
- 基于AI的细分来计算CT扫描预测的肺总体积的百分比 (%pred TLC).
- 低和高%的TLC组之间的关键结果和并发症的比较;在208名患者的随访CT.
主要成果:
- 较低的%pred TLC与较高的临界结局发生率 (14.2%与3.3%,p<0.0001) 有关.
- 患有低%预TLC的患者患有细菌感染,心力衰竭,血栓栓塞,肝脏和功能障碍的比率增加.
- 肺部体积显示出恢复趋势,但在临界病例中在3个月的随访后仍然较低.
结论:
- 减少CT量化的肺体积是COVID-19中关键结果和住院后并发症的重要预测因素.
- CT衍生的肺体积有助于评估疾病严重程度和预测恢复轨迹.
- 较低的肺体积与较慢的临床改善和多器官功能障碍的风险增加相关.
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