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对CKD中不良事件和多病症的互动探索
Inga Steinbrenner1, Fruzsina Kotsis1,2, Robin Kosch3,4
1Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
概括
患有慢性病 (CKD) 的人面临高风险的不良事件和死亡率. 一个交互式工具揭示了事件模式,帮助患者护理和公共卫生政策对这个弱势群体.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 数据科学数据科学数据科学
背景情况:
- 慢性病 (CKD) 患者的不良事件,早期死亡率和多病症的风险增加.
- 目前,在定期科护理下的大量CKD队列中,对不良事件类型和发生率的全面分析缺乏.
- 开发了一种交互式工具,用于在前性,观察性德国CKD (GCKD) 研究中探索不良事件及其组合.
研究的目的:
- 在一个大型CKD队列中提供不良事件类型和发生率的详细概述.
- 开发一种交互式工具,用于探索不良事件及其组合.
- 了解慢性病患者的多病态趋势.
主要方法:
- 德国CKD (GCKD) 研究招募了5217名患有不同CKD阶段和蛋白尿症的参与者.
- 判断心血管,脑血管,外围血管,脏,感染和癌症事件以及死亡事件,遵循标准操作程序.
- 一个R闪亮的应用程序被用于交互探索时间到事件数据,采用多变量调整的考克斯模型,累积发病率函数,卡普兰-梅尔曲线和交叉图.
主要成果:
- 在平均6.5年的时间里,2947名参与者 (56.5%) 发生了10,271起事件,其中680人 (13.0%) 死亡.
- 交互式平台允许对不良事件,它们的组合和CKD死亡率趋势进行审查.
- 观察到每1000个患者年中心血管 (113.6), (75.0) 和感染 (66.0) 事件的高发病率. 糖尿病病和男性性别与更高的事件易感相关.
结论:
- 一个全面的交互工具可视化慢性病患者的不良事件,组合,死亡率和多病症.
- 该资源可以帮助患者护理和识别高风险群体.
- 该工具支持医疗服务和公共卫生政策规划,用于CKD管理.
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