在衰老和血管风险因素的背景下,探索大脑拓弹性和认知表现之间的联系:跨种族基于人口的研究
Hao Liu1, Jing Jing2, Jiyang Jiang3
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191 , China.
Science bulletin
|April 25, 2024
概括
大脑拓弹性 (BTR) 支持在衰老期间的认知功能. 这一指标不受大脑体积的影响,显示出作为客观大脑健康评估工具的希望.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 网络科学 网络科学
背景情况:
- 大脑衰老通常会导致认知能力下降.
- 血管风险因素 (VRF) 和动脉样硬化 (AS) 显著导致与年龄相关的认知障碍.
- 大脑的弹性,即能够承受干扰的能力,对于维持认知功能至关重要,但其在衰老中的作用尚未完全理解.
研究的目的:
- 研究大脑拓弹性 (BTR) 与老年人认知表现之间的关联.
- 探索BTR,衰老,VRF和AS之间的关系.
- 为了确定BTR是否可以作为认知健康的成像标记.
主要方法:
- 利用了来自两个跨种族队列 (PRECISE和MAS) 的数据.
- 在网络攻击模拟中使用k-shell分解和节点中心度来评估BTR.
- 应用结构方程建模 (SEM) 来分析BTR,衰老,VRF,AS和认知之间的方向关系.
主要成果:
- BTR显示了与年龄,VRF和AS的负相关性.
- BTR显示与认知表现有积极的相关性.
- SEM分析证实,老龄化,AS和VRF通过损害BTR而对认知产生负面影响,独立于大脑体积.
结论:
- 大脑拓弹性 (BTR) 在整个衰老过程中在维持认知功能方面发挥着支持作用.
- BTR是一种潜在的成像生物标志物,用于对认知表现的客观评估.
- 了解BTR的作用可以为减轻与年龄相关的认知衰退的策略提供信息.
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