排尿细胞学是一种有用的工具,可以在手术前预测非肌肉侵入性膀癌的风险
Carmen Gómez Del Cañizo1, Ignacio González Ginel1, Cristina Martín-Arriscado Arroba2
1Urology Department, University Hospital 12 de Octubre. Av. de Córdoba, s/n 28041, Madrid, Spain.
Urologic oncology
|April 25, 2024
概括
排空尿细胞学 (VUC) 准确地预测了手术前的非肌肉侵入性膀癌 (NMIBC) 风险. 这种廉价的方法有助于治疗决策和优先考虑高风险患者.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 诊断细胞学 诊断细胞学
背景情况:
- 准确的风险分层对于非肌肉侵入性膀癌 (NMIBC) 管理至关重要.
- 排空性尿细胞学 (VUC) 是一种非侵入性诊断工具,有可能用于手术前的风险评估.
研究的目的:
- 为了评估无效尿细胞学 (VUC) 在预测非肌肉侵入性膀癌 (NMIBC) 风险分层在手术前的准确性.
- 评估VUC在区分高风险和低风险NMIBC中的实用性.
主要方法:
- 在两年内从224名膀癌患者收集前性数据.
- 使用灵敏度,特异性,正预测值 (PPV),负预测值 (NPV),诊断几率比 (DOR) 和ROC曲线分析VUC准确度.
- 对VUC的分类结果为积极的,可疑的,负面的和不典型的风险评估.
主要成果:
- 阳性VUC显示高特异性 (92.4%) 和PPV (91.4%) 对高风险瘤.
- 组合阳性和可疑的VUC显示高风险NMIBC的灵敏度为65%,DOR为9.51.
- 对低风险瘤 (DOR 6.90) 呈现高特异性 (93.2%) 的负VUC.
- 发现非典型的VUC结果最不准确.
结论:
- 排空尿细胞学 (VUC) 是一种有价值,具有成本效益和可访问的方法,用于在膀癌中进行手术前风险分层.
- VUC的发现可以指导有关静脉内化疗灌注和患者优先级的决策.
- 该研究支持在临床实践中用于NMIBC管理的VUC的常规使用.
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