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在生物膜中模拟等离子体介导的水平基因转移

Julien Vincent^1,2, Alberto Tenore¹, Maria Rosaria Mattei³

¹Department of Mathematics and Applications "Renato Caccioppoli", University of Naples Federico II, Via Cintia 26, 80126, Monte S. Angelo, Naples, Italy.

Bulletin of mathematical biology

|April 25, 2024

概括

这项研究模拟了生物膜中的等离子体传播,发现金属和抗生素等污染物可以促进等离子体的持久性. 数学模型显示了这些因素如何影响基因转移和细胞群.

科学领域:

微生物学微生物学
数学生物学数学生物学
生物膜动力学生物膜动力学

背景情况:

等离子体是移动的遗传元素,可以携带抗生素耐药性基因,从而导致全球卫生危机.
由于它们在水平基因转移和适应中的作用,了解生物膜中的等离子体动力学至关重要.

研究的目的:

开发一个数学模型模拟等离子体在不断增长的生物膜中传播.
研究环境因素 (如微量金属和抗生素) 对等离子体持久性和转移的影响.

主要方法:

在1D自由边界域中制定非局部部分微分方程系统.
纳入受体感应机制,以调节基因转移.
包括一个促进功能来模拟微金属对结合的影响.

主要成果:

该模型在质量上与实验观测一致.
发现有毒金属和抗生素等污染物通过有利于等离子体载体和刺激合来促进等离子体持久性.
观察到等离子体传播即使在高度的污染物中也会持续存在,这些污染物会抑制结合,这是由于无等离子体细胞的强烈抑制.

结论:

矛盾的是,环境污染物可以促进生物膜中的等离子体持久性.
数学建模为控制选择性压力下的等离子体动态的复杂相互作用提供了宝贵的见解.
生物膜的活性区域呈现出更高的等离子体密度,正如模型预测的那样.

关键词:

抗微生物耐药性抗微生物耐药性生物膜是一种生物膜.自由边界问题自由边界问题横向的基因转移是可以实现的.非本地PDEs是什么意思等离子体的结合.

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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.