肠内分泌细胞的饮食L-Glu感知通过调节肠道PYY/NPF分泌来调整食物摄入量
Junjun Gao1, Song Zhang1, Pan Deng2,3
1Department of Medical Genetics, School of Basic Medicine, Institute for Brain Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
动物通过肠内分泌细胞 (EECs) 感知氨基酸. 饮食中的谷氨酸会向EEC发出信号,减少神经F (NPF) 的分泌,抑制养行为.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 动物生理学 动物生理学
背景情况:
- 动物监测氨基酸的可用性,以进行营养适应.
- 人们假设肠内分泌细胞 (EECs) 能够感知饮食中的氨基酸并分泌调节性.
- 对于EEC氨基酸感应和激素介导养调制的机制还没有完全了解.
研究的目的:
- 阐明EEC中氨基酸感应的细胞机械.
- 为了研究EEC衍生的荷尔蒙如何调节养行为.
- 在营养感知中识别肠-大脑通信的保存机制.
主要方法:
- 开发专门用于操纵Drosophila中的EEC的工具.
- 在EEC中分析振荡和神经F (NPF) 分泌.
- 研究多巴胺的肠道神经元信号传输和大脑中继.
主要成果:
- 交配的雌性EEC分泌Drosophila神经F (NPF),抑制食,类似于人类PYY.
- 饮食中的L-谷氨酸,通过metabotropic谷氨酸受体 (mGluR) 起作用,减少EEC振荡和NPF分泌.
- 表达NPFR的多巴氨基性肠道神经元接收NPF信号,并向大脑传递一种厌食性信息.
结论:
- 来自EEC的NPF在抑制养行为方面发挥着至关重要的作用.
- 对于饮食成分 (如谷氨酸酸) 的肠道感应来调节养,存在一种保存的机制.
- 这项研究揭示了EEC如何评估食品质量,并通过NPF/PYY途径传达腹信号.
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